What is the Tolerable Upper Intake Level (UL) for vitamin B6 for adults according to the EFSA 2023 opinion, and how does it compare to previous values?

According to the EFSA NDA-Panel scientific opinion from May 17, 2023, the UL for vitamin B6 for adults (including pregnant and breastfeeding women) is 12 mg/day. This value represents a reduction by half from the previous UL of 25 mg/day established by the SCF in 2000. The critical endpoint for this limit is peripheral sensory neuropathy, though the text notes in the subjunctive mood that some experts criticize this reduction as being based on uncertain data.