What role does COMT play in Wechseljahre?

COMT (catechol-O-methyltransferase) degrades catecholamines and estrogen metabolites. During menopause, declining estrogen levels can alter COMT activity. The common rs4680 (Val158Met) SNP affects enzyme efficiency: the Met variant reduces activity, potentially increasing sensitivity to stress, mood swings, and possibly hot flashes or cognitive changes. However, evidence is moderate and largely observational; no clinical guidelines recommend COMT genotyping for menopause management. Lifestyle, hormone therapy, and overall health play a far larger role. Direct-to-consumer tests often overstate the impact. There is no proven supplement to 'boost dopamine' based on COMT status, and such approaches may carry risks. In summary, COMT genetics offer a modest piece of the puzzle but should not drive clinical decisions without broader context.