What to watch with Progesteron and Fruchtbarkeit?

Progesterone is critical for fertility, especially during the luteal phase and early pregnancy. In fertility medicine, progesterone is routinely measured via blood tests and supplemented when needed – for example after IVF or in cases of recurrent miscarriage. Evidence for clinical progesterone testing and supplementation is human-moderate, supported by randomized trials and guidelines. Caution is warranted with direct-to-consumer tests (saliva or DNA) that claim to analyze progesterone-related genetic variants (e.g., in CYP17A1 or CYP1A1). These are not sufficiently validated to guide individual fertility decisions. Over-the-counter progesterone creams are also often marketed without strong evidence; unsupervised use may disrupt the menstrual cycle. Bottom line: Rely on physician-monitored blood tests and supplementation, not genetic tests or self-medication. The evidence for personalized DNA-based progesterone recommendations is currently insufficient.