What role does Transferrin play in Allergie?

Transferrin is an iron-binding protein primarily responsible for iron transport in the blood. Its direct role in allergies is not well established. However, transferrin may indirectly influence immune function through iron homeostasis: both iron deficiency and overload can modulate mast cell and T‑cell activity, which are involved in allergic responses. Some studies report altered transferrin levels in allergic conditions, but findings are inconsistent and evidence is weak. Most data come from animal or in vitro experiments, not large human cohorts. Therefore, a specific clinical role for transferrin in allergies cannot be confirmed. Consumer DNA tests that include transferrin variants typically lack validated allergy risk predictions. Be cautious of marketing claims. Evidence: unclear/mechanistic.