Is VKORC1 useful for allergy?

VKORC1 encodes vitamin K epoxide reductase and is well-established in pharmacogenetics for warfarin sensitivity. There is no robust scientific evidence linking VKORC1 variants directly to allergies or allergic diseases. The gene's role is limited to coagulation pathways. Some speculative connections via vitamin K and immune regulation exist, but they lack clinical validation. Consumer DNA tests that suggest VKORC1 is useful for allergy prediction are overstating the evidence. Allergies are polygenic and involve HLA, cytokine, and IgE-related genes, not coagulation factors. Therefore, VKORC1 testing is not useful for allergy assessment. Evidence grade: marketing/unclear. Caveat: Do not use VKORC1 results to guide allergy management or avoidance strategies.