Is hsCRP useful for Müdigkeit?

hsCRP (high-sensitivity C-reactive protein) is a marker of systemic inflammation. In the context of fatigue, elevated hsCRP may indicate an underlying inflammatory condition (e.g., infection, autoimmune disease, chronic inflammation). However, fatigue is a highly nonspecific symptom; more common causes include sleep deprivation, stress, iron deficiency, or thyroid dysfunction. The evidence for routine hsCRP testing in unexplained fatigue is weak: studies show an association between low-grade inflammation and fatigue, but the predictive value is low. hsCRP can be useful as an adjunctive test when an inflammatory cause is suspected, but it does not replace a thorough history and basic workup. Elevated levels warrant further investigation. Caveat: a normal hsCRP does not rule out inflammation, and mildly elevated levels can be due to lifestyle factors (obesity, smoking). Overall, hsCRP is not a specific fatigue test but a piece in the differential diagnosis.