Is ADH1B useful for Fruchtbarkeit?

The usefulness of ADH1B for fertility is not supported by strong evidence. ADH1B encodes alcohol dehydrogenase, an enzyme that metabolizes ethanol. Certain variants (e.g., ADH1B*2) are associated with lower alcohol intake due to aversive reactions, which could indirectly benefit fertility by reducing alcohol-related harm. However, no direct, well-controlled studies demonstrate that ADH1B genotype predicts fertility outcomes like conception rates, ovarian reserve, or semen quality. The evidence is limited to GWAS associations and mechanistic plausibility. Consumer DNA tests (e.g., MyBody-X) that claim to guide fertility based on ADH1B are overstating the science. For fertility concerns, evidence-based approaches include lifestyle optimization, medical evaluation of hormones and reproductive health, and, if indicated, assisted reproductive technologies. ADH1B testing alone is not clinically useful for fertility.