Is COMT useful for Müdigkeit?

Whether COMT genotyping is useful for fatigue depends on context. COMT (catechol-O-methyltransferase) degrades dopamine, adrenaline, and noradrenaline. The common rs4680 (Val158Met) variant reduces enzyme activity, leading to higher dopamine levels but also increased stress sensitivity and potentially faster mental exhaustion. Some studies link the Met allele to greater cognitive fatigue under load, while others find no clear association with general tiredness. Evidence is moderate, mostly from GWAS and cognitive performance research, not from clinical fatigue trials. A COMT test alone cannot diagnose or treat fatigue. It may offer a piece of the puzzle when combined with other markers (e.g., MAOA, BDNF, cortisol) in a nutrigenetic context. However, fatigue has many causes—sleep deficiency, iron deficiency, thyroid issues, psychological stress—that a genetic test cannot address. MyBody-X tests are lifestyle-oriented, not medical diagnostics. Consumers should consult a physician for persistent fatigue and not rely solely on genetic results.