Evidence check: hsCRP in the context of Langlebigkeit

hsCRP (high-sensitivity C-reactive protein) is a well-established biomarker of systemic inflammation. In the context of longevity, hsCRP is discussed as an indicator of 'inflammaging' – chronic low-grade inflammation that accelerates biological aging. Elevated levels (>1–3 mg/L) are associated with increased risk of cardiovascular disease, metabolic syndrome, and all-cause mortality. However, hsCRP is not a direct longevity test; it reflects acute or low-grade inflammation influenced by infections, lifestyle, and obesity. The evidence for a causal role in longevity is primarily epidemiological and mechanistic (cytokine pathways). A normal hsCRP alone does not guarantee extended lifespan; it must be interpreted alongside other markers (lipids, glucose, blood pressure) and lifestyle factors. Caution: single measurements can be confounded by acute events. For longevity assessment, repeated measures and clinical context are required. Evidence grade: human-moderate (strong association with cardiovascular risk, moderate direct longevity evidence).