When combining MY FOODBOOK (a DNA-based nutrition test) with allergy concerns, a cautious interpretation is essential. MY FOODBOOK analyzes SNPs linked to nutrient metabolism, intolerances (e.g., lactose), or taste preferences. The evidence is mostly from GWAS and observational studies; robust randomized controlled trials are lacking. True food allergies are IgE-mediated immune responses and are not captured by the genetic variants in this test. The test may hint at predispositions for intolerances (e.g., lactase persistence) but cannot diagnose allergies. Effect sizes of most SNPs are small, so results should not guide medical decisions. For allergy evaluation, standard methods (skin prick test, specific IgE, oral food challenge) are required. MY FOODBOOK can serve as a supplementary tool for general dietary tendencies, but it does not replace an allergist. Self-elimination of foods based on genetic results risks nutritional deficiencies. The evidence level is 'mixed': partly mechanistic and GWAS-supported, but lacking clinical validation for allergy outcomes.
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