Is HDL useful for longevity?

The question of whether HDL (high-density lipoprotein) is useful for longevity is debated in the scientific community. HDL is often called 'good cholesterol' because it transports excess cholesterol from arteries to the liver (reverse cholesterol transport). Epidemiological studies show an inverse correlation between HDL levels and cardiovascular events. However, randomized controlled trials and Mendelian randomization studies have not demonstrated a clear causal protective effect of HDL on all-cause mortality or longevity. HDL is a complex lipoprotein with many subclasses and functions beyond cholesterol transport, including antioxidant, anti-inflammatory, and immunomodulatory properties. Functionality (e.g., cholesterol efflux capacity) appears more important than mere concentration. For longevity, many factors matter: genetics (e.g., FOXO3 variants), lifestyle, inflammation, and metabolic health. HDL alone is not a reliable longevity marker. The MyBody-X test context provides no specific HDL data; evidence is based on general research. Thus, individual predictive value is limited. Safety note: HDL levels should always be interpreted in the context of the full lipid profile and individual risk factors.