hsCRP (high-sensitivity C-reactive protein) is a general marker of systemic inflammation, not specific to gut health. Elevated hsCRP can indicate low-grade inflammation that may be linked to gut barrier dysfunction or dysbiosis, but the evidence is primarily observational and not causal. Some studies show associations between hsCRP and altered gut microbiota, but hsCRP alone is insufficient to diagnose gut health issues. For targeted gut assessment, more specific markers like fecal calprotectin, zonulin, or comprehensive stool analysis are recommended. hsCRP can serve as a broad screening tool, but it should not be overinterpreted: normal levels do not rule out gut problems, and elevated levels require medical follow-up. Consumer test results are screening signals, not definitive diagnoses. Evidence level: mixed/unclear.
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