What to watch with FADS1 and Wechseljahre?

FADS1 variants (e.g., rs174546) influence the conversion of alpha-linolenic acid (ALA) into long-chain omega-3 fatty acids EPA and DHA. During menopause, declining estrogen levels are associated with increased inflammation and cardiovascular risk, making omega-3s a common recommendation. However, carriers of the T allele at rs174546 show reduced conversion efficiency and may benefit more from direct EPA/DHA intake (e.g., fish oil). Evidence comes from mechanistic and population studies, but specific intervention trials in menopause are lacking. MyBody-X includes FADS1 in its tests, but the clinical relevance for menopausal symptoms is not firmly established. Caution: high-dose omega-3s can affect blood clotting; consult a physician. Overall, personalized omega-3 advice based on FADS1 during menopause is plausible but not strongly evidence-based.