Skin aging in men results from both intrinsic (genetic) and extrinsic (environmental) factors. Variants in genes like SOD2 (rs4880) or VDR may modestly affect antioxidant defense or collagen metabolism, but effect sizes are small and context‑dependent. More impactful are UV exposure, smoking, diet, and declining testosterone. Consumer DNA tests (e.g., MyBody‑X) can indicate genetic tendencies but cannot predict individual skin aging. Evidence is mechanistic or GWAS‑based, with no strong human trials linking specific SNPs to visible aging outcomes. Caveat: Do not rely on genetic results alone; sun protection, a healthy diet, and avoiding smoking are proven to slow skin aging. Clinical assessment by a dermatologist remains essential.
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