What to watch with HDL and Langlebigkeit?

HDL (high-density lipoprotein) is commonly called 'good cholesterol,' but its link to longevity is nuanced. Moderate HDL levels (40–60 mg/dL) are associated with lower cardiovascular risk, yet very high levels (>80 mg/dL) may indicate dysfunctional HDL and paradoxically increase mortality. HDL function (e.g., cholesterol efflux capacity) matters more than concentration. Genetic variants like ADH1B (affecting alcohol metabolism) can indirectly influence HDL via alcohol intake—alcohol raises HDL, but health risks often outweigh benefits. Consumer DNA tests often overstate these small genetic effects. For longevity, lifestyle factors (exercise, Mediterranean diet, no smoking) are far more impactful. A single HDL measurement does not predict lifespan. Be cautious of marketing that frames HDL as a simple longevity marker.