How are FUT2 and longevity related?

The relationship between FUT2 and longevity is indirect and based on mechanistic reasoning rather than robust human evidence. FUT2 (fucosyltransferase 2) determines secretor status: secretors express ABO blood group antigens in bodily fluids, which shapes gut microbiome composition. Some studies suggest non-secretor status (inactive FUT2) is associated with higher risk of inflammatory bowel disease, vitamin B12 deficiency, and certain infections – factors that could theoretically impair healthspan. However, no direct GWAS or longitudinal studies link FUT2 variants to extended lifespan. The evidence remains mechanistic and speculative. MyBody-X tests can report FUT2 genotype, but interpreting it for longevity is not evidence-based. Clinical takeaway: secretor status may influence gut health, but extending life expectancy through FUT2 alone is unproven. Beware of exaggerated anti-aging claims.