Evidence check: Ferritin in the context of skin aging

Ferritin is an iron storage protein and a key biomarker of body iron status. In the context of skin aging, evidence suggests that both iron overload (elevated ferritin) and iron deficiency (low ferritin) may affect skin health. Excess iron can promote oxidative stress via the Fenton reaction, damaging collagen and elastin, potentially accelerating skin aging. Some observational studies link higher ferritin levels with increased wrinkles or hyperpigmentation. However, the evidence is moderate: no large randomized trials confirm a causal effect. Ferritin also rises as an acute-phase reactant during inflammation, complicating interpretation. A single ferritin measurement without additional iron markers (transferrin saturation, soluble transferrin receptor) has limited value for skin aging assessment. Currently, there is no recommendation to adjust ferritin levels specifically for skin aging prevention.