What role does HLA-DQ2 play in Langlebigkeit?

HLA-DQ2 is a genetic variant strongly linked to celiac disease. About 30–40 % of the population carry HLA-DQ2, but only a minority develop celiac disease. Regarding longevity, HLA-DQ2 does not play a direct causal role. However, untreated celiac disease can lead to chronic inflammation, malabsorption, and nutrient deficiencies (e.g., vitamin D, iron, folate), potentially reducing lifespan. Studies show a slightly increased mortality risk in untreated celiac disease, which normalizes on a gluten-free diet. Thus, the impact of HLA-DQ2 on longevity is indirect and modifiable. A positive test does not mean a shorter lifespan; it indicates an increased risk that can be managed through diagnosis and diet. The evidence is primarily epidemiological and clinical, not specifically focused on longevity. Direct longevity studies on HLA-DQ2 are lacking. Consumer DNA tests for HLA-DQ2 have limited utility—they indicate risk, not diagnosis. If celiac disease is suspected, medical evaluation with antibody tests and biopsy is essential.