Evidence check: COMT in the context of skin aging

The role of COMT in skin aging is not well established. COMT (catechol-O-methyltransferase) metabolizes catecholamines and catechol estrogens. The common Val158Met polymorphism (rs4680) affects enzyme activity: the Met allele reduces activity. Lower COMT activity could theoretically increase levels of catechol estrogens, which may promote oxidative stress and contribute to skin aging. However, direct human evidence linking COMT genotype to skin aging is lacking. Most support comes from mechanistic or animal studies. Consumer DNA tests often include COMT for traits like mood or methylation, not skin aging. Therefore, the evidence level is unclear. It would be premature to change skincare or supplement regimens based solely on this SNP. Sun protection, a balanced diet, and a healthy lifestyle remain the most effective anti-aging measures.