Can Omega-3 Index help with longevity?

The Omega-3 Index measures the percentage of EPA and DHA in red blood cell membranes and is considered a marker of long-chain omega-3 status. Epidemiological studies link higher Omega-3 Index levels to reduced cardiovascular mortality and lower inflammation, both of which are associated with healthier aging. However, direct evidence that a high Omega-3 Index extends human lifespan is limited. Most data come from observational cohorts; randomized controlled trials with lifespan as a primary endpoint are lacking. Additionally, individual response depends on genetic variants (e.g., FADS1) and lifestyle. The index is a useful biomarker but not a guarantee of longevity. Increasing intake via fatty fish or supplements may support cardiovascular health, but should not be seen as a standalone anti-aging intervention. Caution: high doses can increase bleeding risk. Evidence: human-moderate.