What role does CRP Entzündung play in Langlebigkeit?

CRP (C-reactive protein) is a classic inflammatory marker produced in the liver. Chronic low-grade inflammation ('inflammaging') is considered a driver of biological aging and is associated with increased mortality, cardiovascular disease, and frailty. Elevated blood CRP levels therefore correlate with shorter lifespan. However, CRP itself is likely not causal—it is more an indicator of underlying inflammatory processes. Genetic variants such as rs1205 (T allele) slightly lower baseline CRP, but the clinical relevance for longevity is unclear. Some studies suggest that very low CRP might impair immune function. Thus the relationship is not linear. In practice, a CRP blood test provides a current inflammation status, but no direct 'longevity gene'. Lifestyle factors (diet, exercise, sleep) influence inflammation more strongly than single gene variants. Consumer DNA tests for CRP offer only weak hints and should not be used for diagnosis or treatment decisions. Evidence: human-moderate (observational studies, but no robust interventional data).