What role does BDNF play in Wechseljahre?

BDNF (Brain-Derived Neurotrophic Factor) is a key protein for neuronal survival and plasticity. During menopause, declining estrogen levels can modulate BDNF expression – studies suggest a link to cognitive changes and mood fluctuations. However, the provided context contains no specific data on BDNF or menopause. The evidence is therefore mechanistic: estrogen regulates BDNF via the CREB pathway, but direct clinical evidence from the given sources is absent. Interpreting single genetic tests (e.g., BDNF Val66Met) without comprehensive hormonal and lifestyle assessment is not meaningful. For menopausal symptoms, medical evaluation is recommended before considering supplements or therapies.