Can Homocystein help with Langlebigkeit?

The question of whether homocysteine can help with longevity is misleading. Homocysteine is a sulfur-containing amino acid; elevated blood levels (hyperhomocysteinemia) are associated in observational studies with increased risk of cardiovascular disease, cognitive decline, and premature mortality. However, there is no robust evidence that lowering homocysteine – e.g., via supplementation with folic acid, vitamin B12, and B6 – extends lifespan. Randomized controlled trials (RCTs) show mixed results: some found a reduction in stroke risk, but no clear benefit for all-cause mortality. Homocysteine is thus more a risk marker than a direct therapeutic target. A healthy diet providing adequate B vitamins is advisable, but targeted homocysteine lowering without proven deficiency is not recommended as an anti-aging intervention. Evidence: moderate association, but no causal effect on longevity. Safety note: high doses of B vitamins can cause adverse effects (e.g., peripheral neuropathy with excess B6).