High-sensitivity CRP (hsCRP) is a marker of systemic inflammation that can be influenced by sleep. Observational studies link short or poor-quality sleep with modestly elevated hsCRP, likely via increased IL-6 and cortisol. Genetic variants like IL-6 rs1800795 may slightly modify this response, but lifestyle factors dominate. What to watch: aim for 7–9 hours of consistent sleep, good sleep hygiene, and address potential sleep disorders (e.g., apnea). hsCRP alone is not diagnostic; interpret it alongside other markers (e.g., IL-6, TNF-α) and clinical context. Consumer DNA tests for sleep or inflammation have limited predictive power. Caveat: single hsCRP values can fluctuate due to acute infection or stress. Evidence: human-moderate (observational). Sources: context mentions IL-6 rs1800795; general sleep-CRP literature (e.g., PMID: 25900386, 23922110).
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