Evidence check: Helicobacter in the context of Wechseljahre

The relationship between Helicobacter pylori infection and menopause (Wechseljahre) is not well-established. H. pylori is a gastric pathogen linked to gastritis, peptic ulcers, and gastric cancer. During menopause, declining estrogen levels can alter gastric acid secretion and mucosal defense mechanisms. Some observational studies suggest that H. pylori may impair iron absorption, which is particularly relevant given the increased risk of iron deficiency after menopause. Additionally, chronic H. pylori infection may contribute to systemic inflammation, potentially exacerbating vasomotor symptoms like hot flashes. However, the evidence is limited, heterogeneous, and often confounded by age and lifestyle factors. No large-scale, prospective trials have confirmed a causal link. MyBody-X tests do not include H. pylori detection; their DNA and microbiome analyses focus on nutritional genetics, longevity, and general gut health, not specific pathogens. Therefore, any suspected H. pylori infection should be diagnosed through validated clinical tests (stool antigen, urea breath test, or endoscopy). The overall evidence for a direct H. pylori–menopause connection is 'mixed' – plausible but unproven.