How are Progesteron and Müdigkeit related?

Progesterone is a hormone that rises during the luteal phase of the menstrual cycle and has a calming, sleep-promoting effect via GABA-A receptor modulation. Many women report fatigue in the second half of their cycle, and progesterone supplementation (e.g., in hormone replacement therapy or fertility treatments) commonly lists tiredness as a side effect. However, the evidence is largely mechanistic and based on subjective reports; robust clinical trials linking physiological progesterone levels directly to fatigue in healthy individuals are lacking. Other contributors like cortisol, thyroid function, iron status, and sleep hygiene must be considered. A home hormone test (saliva or blood) can provide a snapshot but is not diagnostic due to high intra-individual variability. For persistent fatigue, consult a healthcare provider rather than relying solely on a consumer test.