Estradiol, the primary form of estrogen, plays a significant role in sleep regulation. Fluctuations in estradiol levels—such as during the menstrual cycle, pregnancy, perimenopause, or menopause—can affect sleep quality. Estradiol influences thermoregulation, and declining levels are associated with night sweats and hot flashes that disrupt sleep. It also interacts with neurotransmitters like serotonin and GABA, which are involved in sleep-wake cycles. However, the relationship is complex and bidirectional: poor sleep can also affect hormone levels. While there is substantial evidence from human studies linking estradiol to sleep, individual responses vary. Monitoring estradiol alongside sleep patterns may provide insights, but it is not a standalone diagnostic tool. Lifestyle factors, stress, and other hormones also play important roles. This answer is based on general medical knowledge; the provided context did not contain specific studies on this topic.
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