How are CRP Entzündung and allergy related?

CRP (C-reactive protein) is a general inflammatory marker that rises during acute and chronic inflammation. In allergies—especially allergic rhinitis, asthma, or atopic dermatitis—CRP can be moderately elevated because allergic reactions trigger an inflammatory cascade. However, the link is not specific: CRP also increases with infections, autoimmune diseases, or tissue damage. Studies show an association between elevated CRP and allergic conditions, but the effect size is small to moderate. Moreover, allergic inflammation is primarily driven by IgE, eosinophils, and cytokines like IL-4, IL-5, IL-13, while CRP responds more to systemic IL-6 signals. Thus, CRP is not a specific allergy marker but can serve as a non-specific indicator of accompanying inflammation. For allergy diagnosis, specific IgE tests and clinical symptoms are essential. Evidence: human-moderate. Caveat: CRP alone is insufficient for allergy assessment.