Evidence check: Ferritin Eisenmangel in the context of skin aging

The question of ferritin (iron stores) in the context of skin aging is not directly addressed in the provided contexts. Ferritin is a biomarker for the body's iron reserves. Iron deficiency (low ferritin) can contribute to pale, dry skin, increased wrinkling, and impaired wound healing, as iron is essential for collagen synthesis and cellular respiration. However, the evidence for a direct causal link between ferritin levels and skin aging in humans is limited. Most data come from observational studies or mechanistic work. Some studies suggest that iron deficiency can weaken the skin barrier and promote oxidative stress, potentially accelerating skin aging. Conversely, high ferritin (iron overload) can also be harmful due to iron's pro-oxidant effects. Consumer lab tests for ferritin are common, but interpretation should always be in a clinical context (e.g., inflammation markers, CRP). Without medical evaluation, a single ferritin value can be misleading. The evidence base is rated as 'unclear' because no high-quality RCTs or meta-analyses specifically address ferritin and skin aging. Recommendation: If iron deficiency is suspected (fatigue, pallor, hair loss), a physician should order a complete blood count and ferritin, not just a DTC test.