How are Progesteron and weight loss related?

The relationship between progesterone and weight loss is complex and not well-established. Progesterone is a hormone that rises in the second half of the menstrual cycle and can promote water retention and increased appetite—both factors that may temporarily hinder weight loss. Some research suggests that an imbalance between estrogen and progesterone (e.g., during menopause) may shift fat distribution toward visceral fat. However, there is no strong evidence that progesterone supplementation directly causes weight loss. In fact, hormone replacement therapy containing progesterone can lead to fluid retention and weight gain in some women. The overall evidence is weak, mostly based on observational studies or mechanistic reasoning. Anyone aiming to lose weight should not rely on progesterone supplements but instead focus on calorie balance and medical guidance. Cases of confirmed progesterone deficiency should be evaluated individually by a healthcare provider.