What role does Nährstoffcheck play in skin aging?

The Nährstoffcheck (e.g., MyBody-X DNA test) analyzes genetic variants affecting vitamin, mineral, and antioxidant metabolism – such as MTHFR (folate), SOD2 (oxidative stress), or AQP3 (skin hydration). The premise is that a personalized nutrient plan could slow skin aging. However, the evidence is mixed. For MTHFR and SOD2, human observational studies exist, but no randomized controlled trials directly prove a benefit for skin aging. AQP3 variants are mechanistically plausible but not clinically validated. The COMT 'warrior/worrier' claim was refuted by large GWAS. Moreover, skin aging is heavily influenced by lifestyle factors (UV protection, diet, smoking). A Nährstoffcheck can serve as supplementary insight, but not as a standalone basis for anti-aging interventions. Evidence is rated as 'mixed'.