Evidence check: COMT in the context of longevity

The role of the COMT gene (catechol-O-methyltransferase) in longevity is not clearly established. COMT degrades dopamine and other catecholamines; the common variant rs4680 (Val158Met) alters enzyme activity. Some observational studies suggest links to stress response, cognitive aging, and cardiovascular risk – factors that could indirectly affect lifespan. However, no randomized controlled trials or large longevity cohorts confirm a direct causal effect. The evidence is mostly mechanistic and associative, not clinically validated. Consumer DNA tests that include COMT variants in 'longevity' profiles often overstate their significance. A single gene cannot explain the complex, polygenic nature of longevity. Interactions with environment, lifestyle, and other genes are critical. Conclusion: COMT testing for longevity currently lacks evidence and should not guide preventive decisions. A healthy lifestyle remains the most important factor.