Can COMT help with Langlebigkeit?

Can COMT help with longevity? The evidence is limited and indirect. COMT (catechol-O-methyltransferase) degrades catecholamines like dopamine and norepinephrine. The well-studied Val158Met polymorphism alters enzyme activity: the Met variant reduces activity, which may affect stress resilience, cognitive aging, and estrogen metabolism. Some observational studies and GWAS have linked COMT variants to human longevity, but effect sizes are small and often not replicated. Mechanistically, COMT could influence aging via oxidative stress or neuroprotection, but direct causal evidence is lacking. Consumer DNA tests often market COMT for 'longevity' or 'brain health', but this overstates the science. The current evidence grade is human-moderate at best, with most support from mechanistic or candidate gene studies. For practical longevity advice, proven interventions like caloric restriction, exercise, and sleep hygiene far outweigh any single genetic variant. Caveat: Do not base health decisions solely on COMT results; they are not diagnostic or predictive of lifespan.