C-reactive protein (CRP) is a well-established biomarker for inflammation, produced by the liver in response to cytokines such as IL-6. Normal CRP levels are typically below 5 mg/L, but reference ranges vary by laboratory. Mild elevations (5–10 mg/L) can occur due to lifestyle factors like smoking, obesity, or minor infections. Markedly elevated levels (> 50 mg/L) suggest acute bacterial infection or systemic inflammation. You should see a doctor if your CRP is above the normal range, especially if accompanied by symptoms such as fever, pain, fatigue, or unexplained weight loss. Repeatedly elevated CRP without obvious cause also warrants medical evaluation. CRP alone is not diagnostic; it must be interpreted alongside clinical findings. Seek immediate care for severe symptoms like chest pain or shortness of breath. Note: high-sensitivity CRP (hs-CRP) is used for cardiovascular risk assessment, but its clinical utility is limited to moderate-risk patients and should not be used in isolation. Evidence for CRP as an inflammation marker is strong (human-strong), but no specific sources were provided in the context.
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