Evidence check: hsCRP in the context of Müdigkeit

hsCRP (high-sensitivity C-reactive protein) is a well-established biomarker for systemic inflammation. Elevated hsCRP can indicate an underlying inflammatory process that may contribute to fatigue, for example in chronic diseases, autoimmune conditions, or post-infectious states. However, the evidence for a direct, causal link between hsCRP and fatigue in otherwise healthy individuals without overt inflammation is moderate at best. Many lifestyle factors (sleep, stress, diet, physical activity) influence both hsCRP levels and perceived fatigue. A single hsCRP measurement is therefore insufficient to explain or diagnose fatigue. In clinical practice, hsCRP is primarily used for cardiovascular risk assessment, not for fatigue workup. Consumer lab tests that market hsCRP in the context of fatigue should be interpreted with caution: the clinical utility is limited, and a normal hsCRP does not rule out inflammation-related fatigue. For persistent fatigue, a comprehensive medical evaluation is recommended.