hsCRP (high-sensitivity C-reactive protein) is a well-established marker of systemic inflammation. Epidemiological studies link elevated hsCRP levels to increased risk of cardiovascular disease, type 2 diabetes, and premature mortality—all factors that can shorten lifespan. However, hsCRP is not a direct predictor of longevity. The evidence is based on observational studies (human-moderate), not on randomized controlled trials proving that lowering hsCRP extends lifespan. Moreover, hsCRP is influenced by many factors: infections, injuries, smoking, obesity, stress, and even gum disease. A single elevated reading says little about individual longevity. Consumer tests like MyBody-X can measure hsCRP, but interpretation requires clinical context. Focusing solely on hsCRP without considering lifestyle, genetics, and other biomarkers is misleading. Practically, knowing your hsCRP level may motivate anti-inflammatory lifestyle changes—healthy diet, exercise, weight management—which are proven to improve healthspan. But there is no guarantee of a longer life. Beware of marketing that overstates hsCRP as a 'longevity biomarker.'
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