How are BDNF and skin aging related?

The relationship between BDNF (Brain-Derived Neurotrophic Factor) and skin aging is not well established. BDNF is primarily known as a neurotrophin in the brain, but it is also expressed in skin cells such as keratinocytes and melanocytes. Some preclinical studies suggest BDNF may protect skin from oxidative stress and UV damage by upregulating antioxidant enzymes and modulating inflammatory responses. It may also influence melanocyte function, affecting pigmentation and skin appearance. However, these findings are mostly mechanistic or from animal models; robust human studies linking BDNF genotypes (e.g., rs6265) to skin aging are lacking. Evidence is therefore mechanistic and preliminary. A consumer DNA test for BDNF variants cannot reliably predict skin aging risk. Factors like UV exposure, diet, and lifestyle are far more influential. Be cautious of marketing claims that label BDNF as an 'anti-aging gene'.