Risks and limits of Gluten Labor

The question about risks and limits of gluten laboratory tests (e.g., genetic tests for gluten intolerance or celiac disease) is important. However, the provided context contains no specific data on gluten testing. Therefore, only general limitations can be stated: Genetic tests for HLA-DQ2/DQ8 can indicate a predisposition for celiac disease but are not diagnostic. A positive result does not necessarily mean active disease; duodenal biopsy remains the gold standard. Commercial tests often overstate the predictive power of single genes. For non-celiac gluten sensitivity, there is no validated biomarker. Risks include false reassurance (e.g., avoiding gluten despite a negative test) or unnecessary dietary restrictions. Evidence is unclear because most tests lack clinical validation. Caveat: Do not change diet based solely on such tests without professional medical evaluation.