How to prepare for MTHFR Basis

The MTHFR Basis test from MyBody-X analyzes common variants in the MTHFR gene (C677T, A1298C) that can affect the activity of the methylenetetrahydrofolate reductase enzyme, which is involved in folate metabolism and homocysteine regulation. **Preparation:** No special preparation is needed for the DNA test itself – a saliva sample is sufficient. However, you should understand that the test does not provide a diagnosis; it only indicates a genetic predisposition. Elevated homocysteine can only be confirmed through a blood test. **Evidence:** The association between MTHFR variants and elevated homocysteine is well-established (human-moderate). However, the benefit of supplementing with active folate (5-MTHF) is individual and not clinically relevant for all carriers. Many health claims in direct-to-consumer marketing are exaggerated. **Safety note:** Do not take high-dose folic acid supplements without medical advice, especially if you are on other medications. For those planning pregnancy or already pregnant, medical consultation is essential.