Is Pharmakogenetik Medicheck useful for Müdigkeit?

Pharmacogenetics (e.g., Medicheck) analyzes how genes affect drug metabolism. For non-specific fatigue, its usefulness is questionable. Fatigue has many causes: sleep deprivation, stress, iron deficiency, thyroid disorders, depression, or chronic infections. A genetic test can rarely pinpoint a clear cause – except in very rare enzyme deficiencies (e.g., CYP2D6 or MTHFR variants) that alter drug or folate processing. Evidence is mostly mechanistic or limited to single SNPs; clinical trials directly linking pharmacogenetics to fatigue improvement are lacking. Most tested variants are common in the population and have small effects. A blood count, vitamin levels, and a medical workup are far more informative. Without a specific medication or known side effects, the test is not recommended for fatigue. Marketing often overstates the real benefit.