Evidence check: FUT2 in the context of Wechseljahre

The role of the FUT2 gene in menopause is not scientifically established. FUT2 determines secretor status and influences vitamin B12 absorption and susceptibility to certain infections (e.g., norovirus). Some studies explore links between B12 deficiency and menopausal symptoms, but there is no robust, reproducible evidence for a direct association of FUT2 variants with menopause onset or progression. Consumer DNA tests often include FUT2 in the context of nutrient metabolism or immune function, not specifically for menopause. The evidence is therefore unclear/speculative. Relying solely on FUT2 genotyping for menopause assessment is not supported. Clinical parameters such as age, hormone levels, and symptoms remain essential.