Is Longevity DNA Test useful for fatigue?

A Longevity DNA test is not useful for diagnosing or managing fatigue. Fatigue is a complex symptom with many potential causes: poor sleep, chronic stress, nutritional deficiencies, thyroid dysfunction, infections, or mental health issues. The genetic variants typically included in such tests (e.g., circadian rhythm genes like CLOCK/BMAL1, or methylation-related MTHFR) have small effect sizes and lack clinical validation for fatigue. Evidence is mostly mechanistic or from GWAS with limited individual predictive power. Consumer DNA tests cannot replace a thorough medical workup. A more evidence-based approach includes blood tests (iron, vitamin D, B12, thyroid panel) and sleep assessment. While the test may offer some general lifestyle hints, it should not guide treatment decisions. Safety note: Do not change diet or supplements based solely on DNA results without consulting a healthcare professional.