Evidence check: Leaky Gut Test in the context of menopause

Evidence for 'leaky gut' tests (e.g., zonulin, LPS, IgG) in the context of menopause is weak. Menopause-related hormonal changes may affect gut permeability, but available tests are not well validated. IgG tests indicate food exposure, not intolerance or permeability. Genetic tests (e.g., for zonulin genes) lack clinical relevance. The evidence base is marketing-driven; professional guidelines advise against such testing. For menopause symptoms, medically supervised approaches (diet, hormone therapy) are more appropriate. These tests do not provide a reliable basis for treatment decisions.