How are FTO and Abnehmen related?

The relationship between FTO and weight loss is often overstated. FTO variants (e.g., rs9939609) are associated with a modest increase in BMI (~0.4 kg/m² per risk allele) in large GWAS. However, a high-quality IPD meta-analysis of 8 RCTs (n=9563) found that FTO genotype does not predict differential weight loss response to low-carb vs. low-fat diets. The effect size is small, and lifestyle factors (calorie balance, physical activity, sleep) dominate. Nutrigenetic tests can offer insights but should not be used as a prescription. Evidence is strong that FTO alone is not a reliable guide for personalized dieting.