How are CRP Entzündung and longevity related?

CRP (C-reactive protein) is a well-established biomarker of systemic inflammation. Chronically elevated CRP levels (≥3 mg/L) are associated in epidemiological studies with accelerated biological aging, increased cardiovascular mortality, and reduced life expectancy. However, the link to longevity is indirect: CRP itself likely does not cause aging but reflects underlying chronic low-grade inflammation—a key driver of 'inflammaging'. Meta-analyses show CRP as an independent risk factor for cardiovascular disease and all-cause mortality, with moderate effect sizes (HR ~1.2–1.5). Importantly, CRP is not a direct longevity marker; there is no evidence that lowering CRP alone extends lifespan. Lifestyle factors such as Mediterranean diet, exercise, and smoking cessation lower CRP while promoting longevity—this is where practical relevance lies. Evidence comes from large cohorts and systematic reviews, not from randomized trials targeting CRP. Caveat: single CRP measurements are non-specific; acute infections confound results. No diagnosis or therapy without medical evaluation.