How are tTG IgA and Schlaf related?

tTG IgA (tissue transglutaminase IgA) is the primary serological marker for celiac disease, an autoimmune enteropathy triggered by gluten. A positive tTG IgA indicates active celiac disease with high probability, provided no IgA deficiency is present. The link to sleep („Schlaf“) is indirect but clinically relevant: untreated celiac disease can impair sleep quality through several mechanisms, including nocturnal abdominal pain, diarrhea, heartburn, or restless legs syndrome (RLS) due to iron, vitamin B12, or folate deficiencies. Additionally, systemic inflammation (cytokines) may disrupt sleep architecture. After initiating a gluten-free diet, many patients report improved sleep. However, the evidence base relies mostly on observational studies and case reports; randomized controlled trials are scarce. Thus, the association is considered moderate. A single tTG IgA test without clinical context cannot reliably predict sleep disturbances. For sleep issues with suspected celiac disease, a full diagnostic workup (including duodenal biopsy) is warranted.