Myths vs facts: BDNF and Langlebigkeit

**Myths vs. Facts: BDNF and Longevity** **Myth:** High BDNF levels guarantee a long life. **Fact:** BDNF (Brain-Derived Neurotrophic Factor) supports neuron survival and plasticity. Observational studies link higher BDNF to better cognitive aging, but a causal role in extending lifespan is unproven. BDNF rises with exercise, intermittent fasting, and sleep, but effects are modest and individual. **Myth:** A DNA test can reveal a 'longevity BDNF gene'. **Fact:** SNPs like rs6265 (Val66Met) alter BDNF secretion, but effect sizes are small and not predictive of lifespan. Evidence comes from GWAS and mechanistic studies, not clinical trials for longevity. Genetic testing for BDNF is not clinically actionable. **Myth:** BDNF supplements (e.g., 7,8-dihydroxyflavone) boost longevity. **Fact:** No human long-term data support lifespan extension. Most supplements lack regulation; high doses may cause side effects. The safest BDNF enhancer remains regular aerobic exercise and a balanced diet. **Bottom line:** BDNF is a promising biomarker for brain health, not a longevity gene. Evidence is moderate (associational). Consumers should be wary of marketing hype.