Myths vs facts: FTO and Haut

The FTO gene is primarily linked to obesity, not directly to skin. Some studies suggest a weak association between certain FTO variants and melanoma risk, likely mediated through BMI. Direct effects on skin aging, wrinkles, or eczema are not supported by strong human evidence. Direct-to-consumer tests often overstate these links. The evidence is moderate and based on GWAS associations. A single FTO SNP is not predictive for skin conditions. Lifestyle, UV exposure, and polygenic risk scores are more relevant. Be cautious of marketing claims: FTO is not a 'skin gene'. Clinical actionability is low.