What role does AMH play in weight loss?

AMH (Anti-Müllerian Hormone) is primarily a marker of ovarian reserve, produced by granulosa cells in the ovaries. There is no direct, causally established role for AMH in weight loss. However, some studies suggest an indirect link: in women with PCOS (polycystic ovary syndrome), AMH levels are often elevated, and PCOS is frequently associated with insulin resistance and weight issues. Weight reduction in PCOS patients can lower AMH levels, which likely reflects improved metabolic status rather than a direct AMH effect. Additionally, there is mechanistic evidence that AMH may influence lipid metabolism via the FSH receptor, but the evidence is weak and purely mechanistic. For the general population, AMH is not a relevant biomarker for weight loss. Measuring AMH in weight management programs is currently not supported by clinical guidelines. In summary: AMH plays no proven direct role in weight loss; observed associations are mostly due to underlying endocrine disorders.