Is Zöliakie Test useful for Darmgesundheit?

A celiac test (e.g., HLA-DQ2/DQ8 genotyping or tissue transglutaminase antibodies) can be useful if celiac disease is suspected, but it is not a general gut health screening tool. Celiac disease is an autoimmune enteropathy triggered by gluten, leading to intestinal damage. A genetic test for HLA-DQ2/DQ8 can rule out celiac with high confidence (negative predictive value >99 %), but cannot confirm the disease – that requires antibody tests and duodenal biopsy. For vague gut symptoms like bloating, diarrhea, or fatigue, a celiac test may help identify a cause. However, many other conditions affect gut health (IBS, SIBO, food intolerances). Direct-to-consumer genetic tests alone lack diagnostic validation. Evidence: human-strong for diagnostic exclusion, but DTC tests often have limited clinical validity. Caveat: a positive genetic result does not mean active celiac; many carriers remain asymptomatic.